GROWTH & REPAIR, IMMUNE & INFLAMMATORY, HAIR & AESTHETICS
BPC-157/TB-500 "WOLVERINE"
5MG/5MG
The BPC-157/TB-500 "Wolverine" protocol is often used to accelerate healing of muscles, tendons, ligaments, and joints. It combines BPC-157, a naturally occurring peptide recognized for its ability to repair tissue with TB-500, a short fragment of the protein Thymosin Beta-4, for sustained regeneration and blood flow.
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MOLECULAR FORMULA
C152H252N44042 / C38H49N905
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Product Usage: For Research Use Only – Not for Human or Veterinary Use
This product is not a drug, food, cosmetic, or dietary supplement and has not been evaluated by the FDA. It is strictly intended for in vitro research by qualified professionals. Any use in humans or animals is strictly prohibited and may violate federal, state, or local laws, including the Federal Food, Drug, and Cosmetic Act. No therapeutic or diagnostic application is implied or permitted. The purchaser assumes all responsibility for compliance with applicable regulations.
BPC-157/TB-500 Research Peptide Blend
The BPC-157/TB-500 "Wolverine" protocol is often used to accelerate healing of muscles, tendons, ligaments, and joints. It combines BPC-157, a naturally occurring peptide recognized for its ability to repair tissue with TB-500, a short fragment of the protein Thymosin Beta-4, for sustained regeneration and blood flow.
Chemical Info
CAS Number
BPC-157: 137525-51-0 TB-500: 885340-08-9
PubChem CID
BPC-157: 9941957 TB-500: 62707662
Molecular Weight
BPC-157: 1419.54 g/mol TB-500: 4963.44 g/mol
Molecular Formula
BPC-157: C62H98N16O22 TB-500: C212H350N56O78S
Synonyms
BPC-157, TB-500, Thymosin Beta-4 (TB4)
Purity
≥ 99% HPLC
Storage
Store in lyophilized form at -20°C to maintain compound stability.
Store protected from direct light exposure to reduce degradation.
Keep totally dry and avoid moisture exposure prior to reconstitution.
Keep vial tightly sealed when not in use to preserve integrity.
Synergistic Vascular Remodeling & VEGFR2 Signaling
BPC-157 and TB-500 are primary foci for investigating the formation of new blood vessels, particularly in ischemic tissue models. Research suggests this blend activates the VEGFR2–PI3K–Akt–eNOS axis, promoting the recruitment of collateral blood vessels to bypass occluded vascular structures. Unlike standard growth factors, this complex is studied for its ability to promote "angiogenic privilege," facilitating healing without inducing pathological neovascularization or neotumorigenesis. Scientists monitor the coordination between vessel recruitment and endothelial cell migration to understand revascularization kinetics.
GHR Upregulation & Connective Tissue Repair
In orthopedic research, this synergistic blend is used to evaluate the potential for accelerated healing in tendons, ligaments, and skeletal muscle. Studies indicate the BPC-157 component upregulates the expression of growth hormone receptors (GHR) in tendon fibroblasts, which potentiates the anabolic response to injury. Simultaneously, the TB-500 component enhances FAK–paxillin pathway activation to determine the rate of cell migration and collagen synthesis. This dual-action approach allows researchers to study the restoration of biomechanical function in poorly vascularized soft tissues.
Cytoprotection & The Brain-Gut Axis
The complex is utilized to study the concept of "Robert's Cytoprotection," focusing on the maintenance of mucosal and endothelial integrity. Researchers examine the impact of these localized signaling molecules on the gastric mucosal barrier and their potential neuroprotective effects against central nervous system disturbances. This research explores how the combined administration of these peptides can counteract inflammation and modulate neurotransmitter balance in models of traumatic or surgical injury, providing a framework for understanding brain-gut axis stabilization.
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